Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration.

<h4>Background</h4>Meta-analyses of antidepressant medications have reported only modest benefits over placebo treatment, and when unpublished trial data are included, the benefit falls below accepted criteria for clinical significance. Yet, the efficacy of the antidepressants may also d...

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Bibliographic Details
Main Authors: Irving Kirsch, Brett J Deacon, Tania B Huedo-Medina, Alan Scoboria, Thomas J Moore, Blair T Johnson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-02-01
Series:PLoS Medicine
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18303940/?tool=EBI