Six New Polyketide Decalin Compounds from Mangrove Endophytic Fungus Penicillium aurantiogriseum 328#

• Main Authors: Yanhong Ma, Jing Li, Meixiang Huang, Lan Liu, Jun Wang, Yongcheng Lin
• Format: Article
• Language: English
• Published: MDPI AG 2015-10-01
• Series: Marine Drugs
• Subjects: mangrove endophytic fungi; Penicillium aurantiogriseum; secondary metabolites; polyketide decalin derivative
• Online Access: http://www.mdpi.com/1660-3397/13/10/6306

Six new compounds with polyketide decalin ring, peaurantiogriseols A–F (1–6), along with two known compounds, aspermytin A (7), 1-propanone,3-hydroxy-1- (1,2,4a,5,6,7,8,8a-octahydro-2,5-dihydroxy-1,2,6-trimethyl-1-naphthalenyl) (8), were isolated from the fermentation products of mangrove endophytic fungus Penicillium aurantiogriseum 328#. Their structures were elucidated based on their structure analysis. The absolute configurations of compounds 1 and 2 were determined by 1H NMR analysis of their Mosher esters; the absolute configurations of 3–6 were determined by using theoretical calculations of electronic circular dichroism (ECD). Compounds 1–8 showed low inhibitory activity against human aldose reductase, no activity of inducing neurite outgrowth, nor antimicrobial activity.