Basal Cell Carcinoma in Gorlin's Patients: a Matter of Fibroblasts-Led Protumoral Microenvironment?

Basal Cell Carcinoma in Gorlin's Patients: a Matter of Fibroblasts-Led Protumoral Microenvironment?

Basal cell carcinoma (BCC) is the commonest tumor in human. About 70% sporadic BCCs bear somatic mutations in the PATCHED1 tumor suppressor gene which encodes the receptor for the Sonic Hedgehog morphogen (SHH). PATCHED1 germinal mutations are associated with the dominant Nevoid Basal Cell Carcinoma...

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Main Authors: Yannick Gache, Florence Brellier, Sophie Rouanet, Sahar Al-Qaraghuli, Maria Goncalves-Maia, Elodie Burty-Valin, Stéphanie Barnay, Sabine Scarzello, Martial Ruat, Nicolas Sevenet, Marie-Françoise Avril, Thierry Magnaldo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4687848?pdf=render

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