| Summary: | Objective: The use of fibrin adhesives has a broad background in nerve repair. Currently the suboptimal physical properties of singledonor fibrin adhesives have restricted their usage. The present experiment studies the performance and physical
characteristics of a modified fibrin glue prepared from
single-donor human plasma in the repair of posterior tibial nerve of rat.
Methods: Forty Wistar rats were divided into 5
groups; in the control group, tibial nerve was completely transected and no treatment was done, while in the four experimental groups the nerve stumps were reconnected
by one suture, three sutures, one suture with fibrin glue and fibrin glue alone respectively. During 8 weeks of follow-up, Tibial Function Index was measured weekly and adhesive strength, inflammation and scar formation
were assessed at the end of the study.
Results: Nerve stumps dehiscence rate and adhesive strength were similar in all experimental groups and significantly differed from control group (P<0.05). By
the end of the eighth follow-up week, functional recovery of one and three sutures groups were signifi cantly higher
than groups in which fibrin glue was used for repair (P<0.05). The amount of inflammation and scar tissue formation was similar among all groups.
Conclusion: The study results show that the
prepared single-donor fibrin adhesive has acceptable mechanical properties which could provide required adhesiveness and hold nerve stumps in the long term; yet, we acknowledge that more studies are needed to improve
functional outcome of single donor fi brin adhesive repair.
Key words: Rats; Nerve regeneration; Fibrin
tissue adhesive; Materials testing
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