Localization of the physiological prion and Na+–K+ ATPase activity in tissues of rats prion-replicating system

• Main Authors: M. V. Kushkevych, V. V. Vlizlo, Y. V. Martyn
• Format: Article
• Language: English
• Published: Львівський національний університет імені Івана Франка 2011-12-01
• Series: Біологічні студії
• Subjects: prion-replicating organs; physiological prion; na+–k+ атpase; sodium and potassium ions
• Online Access: http://publications.lnu.edu.ua/journals/index.php/biology/article/view/394

Immunohistochemical studies of prion-replicating tissues, in six months rats, showed presence of the physiological prion in small intestine, particularly in cells of the jejunum villi own plate – lymphocytes and monocytes. In spleen, physiological prion localization was found in red pulp lymphocytes, located near the capsule and tra­becules. In cells of white pulp the physiological prion was not found. Instead, most of it was located in microgluecytes of medulla oblongata. The Na+–K+ ATPase activity and the concentration of sodium and potassium ions in rat prion-replicating organs were determined. Enzyme activity was highest in the medulla oblongata, and the concentration of ions – in spleen. A direct positive correlation between the amount of physiological prion and the activity of Na+–K+ ATPase was established.