Localization of the physiological prion and Na+–K+ ATPase activity in tissues of rats prion-replicating system
Immunohistochemical studies of prion-replicating tissues, in six months rats, showed presence of the physiological prion in small intestine, particularly in cells of the jejunum villi own plate – lymphocytes and monocytes. In spleen, physiological prion localization was found in red pulp lymphocytes...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Львівський національний університет імені Івана Франка
2011-12-01
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| Series: | Біологічні студії |
| Subjects: | |
| Online Access: | http://publications.lnu.edu.ua/journals/index.php/biology/article/view/394 |
| Summary: | Immunohistochemical studies of prion-replicating tissues, in six months rats, showed presence of the physiological prion in small intestine, particularly in cells of the jejunum villi own plate – lymphocytes and monocytes. In spleen, physiological prion localization was found in red pulp lymphocytes, located near the capsule and trabecules. In cells of white pulp the physiological prion was not found. Instead, most of it was located in microgluecytes of medulla oblongata. The Na+–K+ ATPase activity and the concentration of sodium and potassium ions in rat prion-replicating organs were determined. Enzyme activity was highest in the medulla oblongata, and the concentration of ions – in spleen. A direct positive correlation between the amount of physiological prion and the activity of Na+–K+ ATPase was established. |
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| ISSN: | 1996-4536 2311-0783 |