Effect of immune stimulator Ismigen on immunological indicators of children with obstructive bronchitis

• Main Authors: T. B. Kasokhov, Z. A. Tsoraeva, O. T. Bekuzarova, S. V. Turieva, A. I. Mazur
• Format: Article
• Language: Russian
• Published: Ltd. “The National Academy of Pediatric Science and Innovation” 2018-03-01
• Series: Rossijskij Vestnik Perinatologii i Pediatrii
• Subjects: children; obstructive bronchitis; immunotherapy; bacterial lysates; cytokines; immunoglobulins
• Online Access: https://www.ped-perinatology.ru/jour/article/view/626

One of the leading positions among the infant diseases belongs to the pathology of the respiratory tract. The causes of the obstructive bronchitis in children are very diverse including those, which can be associated with the disorder of the normal immune system functioning or immunodeficiency state. The purpose of the study is to determine the nature of the immune disorders in the children with the obstructive bronchitis, to assess the efficiency of the immunocorrecting therapy. For 2 groups of the children with the obstructive bronchitis, the comparative study with determination of the cytokine and immunoglobulin levels in the blood serum against the background of standard therapy (1st group) and against the background with immune stimulator ismigen included into the therapy was carried out; the ismigen is a multivalent antigenic complex of the bacterial lysates. The efficiency of the immune-enhancing therapy carried out towards the immune system condition of children during the comprehensive treatment of the obstructive bronchitis was shown. The practical importance of the work is to optimize diagnosis and immunocorrection in obstructive bronchitis in children, accompanied by the disorder of the body’s immunoreactivity.