Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance

Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance

Summary: Hhex encodes a homeobox transcriptional regulator important for embryonic development and hematopoiesis. Hhex is highly expressed in NK cells, and its germline deletion results in significant defects in lymphoid development, including NK cells. To determine if Hhex is intrinsically required...

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Bibliographic Details
Main Authors: Wilford Goh, Sebastian Scheer, Jacob T. Jackson, Soroor Hediyeh-Zadeh, Rebecca B. Delconte, Iona S. Schuster, Christopher E. Andoniou, Jai Rautela, Mariapia A. Degli-Esposti, Melissa J. Davis, Matthew P. McCormack, Stephen L. Nutt, Nicholas D. Huntington
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
NK cells
proliferation
survival
apoptosis
BIM
transcriptional regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720312742

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