Dual effect of beta-amyloid on α7 and α4β2 nicotinic receptors controlling the release of glutamate, aspartate and GABA in rat hippocampus.

Dual effect of beta-amyloid on α7 and α4β2 nicotinic receptors controlling the release of glutamate, aspartate and GABA in rat hippocampus.

BACKGROUND: We previously showed that beta-amyloid (Aβ), a peptide considered as relevant to Alzheimer's Disease, is able to act as a neuromodulator affecting neurotransmitter release in absence of evident sign of neurotoxicity in two different rat brain areas. In this paper we focused on the h...

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Bibliographic Details
Main Authors: Elisa Mura, Stefania Zappettini, Stefania Preda, Fabrizio Biundo, Cristina Lanni, Massimo Grilli, Anna Cavallero, Guendalina Olivero, Alessia Salamone, Stefano Govoni, Mario Marchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3256170?pdf=render

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http://europepmc.org/articles/PMC3256170?pdf=render

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