Identification of a novel TGFβ/PKA signaling transduceome in mediating control of cell survival and metastasis in colon cancer.

Identification of a novel TGFβ/PKA signaling transduceome in mediating control of cell survival and metastasis in colon cancer.

Understanding drivers for metastasis in human cancer is important for potential development of therapies to treat metastases. The role of loss of TGFβ tumor suppressor activities in the metastatic process is essentially unknown.Utilizing in vitro and in vivo techniques, we have shown that loss of TG...

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Bibliographic Details
Main Authors: Sanjib Chowdhury, Gillian M Howell, Ashwani Rajput, Carol A Teggart, Lisa E Brattain, Hannah R Weber, Aparajita Chowdhury, Michael G Brattain
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3086924?pdf=render

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http://europepmc.org/articles/PMC3086924?pdf=render

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