Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury

Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury

Abstract Background We have reported that polydatin (PD) alleviates mitochondrial dysfunction in rat models of sepsis-induced acute kidney injury (SI-AKI), but the mechanism is not well understood. Here, we investigated the role of Parkin-mediated mitophagy in the protective effects of PD in SI-AKI...

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Bibliographic Details
Main Authors: Youguang Gao, Xingui Dai, Yunfeng Li, Guicheng Li, Xianzhong Lin, Chenmu Ai, Yuanyuan Cao, Tao Li, Bo Lin
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Translational Medicine
Subjects:
Polydatin
Acute kidney injury
Mitophagy
Mitochondria
Inflammasome
Online Access:http://link.springer.com/article/10.1186/s12967-020-02283-2

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http://link.springer.com/article/10.1186/s12967-020-02283-2

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