Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer

Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer

By integrating ATP aptamer into the linker DNA, a novel DNA hydrogel was designed, with mechanical properties that could be tuned into three phases. Based on the unique interaction between ATP and its aptamer, the mechanical strength of the hydrogel increased from 204 Pa to 380 Pa after adding ATP....

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Bibliographic Details
Main Authors: Hengyuan Liu, Tianyang Cao, Yun Xu, Yuanchen Dong, Dongsheng Liu
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:International Journal of Molecular Sciences
Subjects:
nucleic acid nanotechnology
DNA nanotechnology
DNA hydrogel
Online Access:http://www.mdpi.com/1422-0067/19/6/1633
Description
Summary:By integrating ATP aptamer into the linker DNA, a novel DNA hydrogel was designed, with mechanical properties that could be tuned into three phases. Based on the unique interaction between ATP and its aptamer, the mechanical strength of the hydrogel increased from 204 Pa to 380 Pa after adding ATP. Furthermore, with the addition of the complementary sequence to the ATP aptamer, the mechanical strength could be increased to 570 Pa.
ISSN:1422-0067

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