Tiam1/Rac1 complex controls Il17a transcription and autoimmunity
Tiam1 is a guanine nucleotide exchange factor for the Rho-family GTPase Rac1. Here, the authors show that nuclear Tiam1 and Rac1 bind to RORγt on the IL-17 promoter, activating its transcription, and that inhibiting Tiam1/Rac1 is beneficial in a mouse model of autoimmunity.
Bibliographic Details
| Main Authors: |
Ahmed T. Kurdi,
Ribal Bassil,
Marta Olah,
Chuan Wu,
Sheng Xiao,
Mariko Taga,
Michael Frangieh,
Thomas Buttrick,
William Orent,
Elizabeth M. Bradshaw,
Samia J. Khoury,
Wassim Elyaman |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2016-10-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms13048
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