Neuronal TGF-β1 mediates IL-9/mast cell interaction and exacerbates excitotoxicity in newborn mice

Neuronal TGF-β1 mediates IL-9/mast cell interaction and exacerbates excitotoxicity in newborn mice

Intraneocortical injection of ibotenate, a glutamate analog, in newborn mice produces damage mimicking lesions observed in human infants with cerebral palsy. Previous research using this model has demonstrated that pretreatment with IL-9, a Th2 cytokine, significantly exacerbated excitotoxic brain l...

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Bibliographic Details
Main Authors: Bettina Mesplès, Romain H. Fontaine, Vincent Lelièvre, Jean-Marie Launay, Pierre Gressens
Format: Article
Language:English
Published: Elsevier 2005-02-01
Series:Neurobiology of Disease
Subjects:
Cerebral palsy
Cytokines
Glutamate
Histamine
Kit
N-methyl-d-aspartate
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104002323

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