Studying biomolecular folding and binding using temperature-jump mass spectrometry

Native mass spectrometry allows monitoring the folding and interactions of multiple coexisting species but its temporal resolution is traditionally limited. Here, the authors develop a temperature-jump electrospray source for mass spectrometry that enables fast kinetics experiments at different temp...

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Bibliographic Details
Main Authors: Adrien Marchand, Martin F. Czar, Elija N. Eggel, Jérôme Kaeslin, Renato Zenobi
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-14179-x

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