Immunological response in cases of complicated and uncomplicated bartonellosis during pregnancy Respuesta inmunologica en casos de bartonelosis con y sin complicaciones durante el embarazo

• Main Authors: Erick Huarcaya, Ciro Maguina, Ivan Best, Nelson Solorzano, Lawrence Leeman
• Format: Article
• Language: English
• Published: Universidade de São Paulo 2007-10-01
• Series: Revista do Instituto de Medicina Tropical de São Paulo
• Subjects: Carrion's Disease; Pregnancy; Immunology
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652007000500012

Bartonellosis (Carrion's Disease) during pregnancy is associated with high rates of maternal and perinatal mortality. We report the immunological patterns in two cases of human bartonellosis during pregnancy. One patient had an uncomplicated course while the second patient developed life threatening anasarca and cardiac tamponade. The patient with a complicated course had a Th1 response with a higher elevation of IL-10. This elevation has been associated with poor outcome pregnancies during bacterial infections.<br>Bartonelosis (Enfermedad de Carrión) durante el embarazo esta asociado a una alta tasa de mortalidad maternal y perinatal. Reportamos el perfil inmunológico de dos casos de Bartonelosis humana en el embarazo. Una paciente tuvo un curso sin complicaciones, mientras la segunda presento complicaciones severas de anasarca y tamponamiento cardiaco. La paciente con curso complicado tuvo un patrón de repuesta Th1, con una elevación de IL-10, que se ha asociado a mal pronóstico en infecciones durante embarazo.