Widespread intronic polyadenylation diversifies immune cell transcriptomes

Widespread intronic polyadenylation diversifies immune cell transcriptomes

Recognition of intronic polyadenylation (IpA) signals can lead to expression of truncated proteins lacking C terminal domains. Analysis of 3ʹ -seq and RNA-seq shows that IpA is widespread in circulating immune cells, while multiple myeloma cells show loss of IpA isoforms that are normally expressed...

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Bibliographic Details
Main Authors:	Irtisha Singh, Shih-Han Lee, Adam S. Sperling, Mehmet K. Samur, Yu-Tzu Tai, Mariateresa Fulciniti, Nikhil C. Munshi, Christine Mayr, Christina S. Leslie
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-04112-z

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