Serum and Urinary Interleukin-6 in Assessment of Renal Activity in Egyptian Patients with Systemic Lupus Erythematosus

Aim of the Work This study investigates whether serum and urinary interleukin-6 (IL-6) represent an early marker of kidney involvement and assesses the difference between them and renal biopsy in lupus nephritis (LN). Patients and Methods A total of 60 systemic lupus erythematosus (SLE) patients wer...

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Main Authors: Rawhya R. EL-Shereef, Ahmed Lotfi, Emad A. Abdel-Naeam, Heba Tawfik
Format: Article
Language:English
Published: SAGE Publishing 2016-01-01
Series:Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders
Online Access:https://doi.org/10.4137/CMAMD.S32269
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spelling doaj-2b9f4c9fd4ad474c8502482e2c6c18202020-11-25T03:32:04ZengSAGE PublishingClinical Medicine Insights: Arthritis and Musculoskeletal Disorders1179-54412016-01-01910.4137/CMAMD.S32269Serum and Urinary Interleukin-6 in Assessment of Renal Activity in Egyptian Patients with Systemic Lupus ErythematosusRawhya R. EL-Shereef0Ahmed Lotfi1Emad A. Abdel-Naeam2Heba Tawfik3Department of Rheumatology and RehabilitationDepartment of Rheumatology and RehabilitationDepartment of Clinical PathologyDepartment of Histopathology, Faculty of Medicine, Minia University, Minia, Egypt.Aim of the Work This study investigates whether serum and urinary interleukin-6 (IL-6) represent an early marker of kidney involvement and assesses the difference between them and renal biopsy in lupus nephritis (LN). Patients and Methods A total of 60 systemic lupus erythematosus (SLE) patients were compared to 20 healthy controls. Urinary and serum IL-6 were measured in both patients and controls. In addition, renal biopsy was done prior or shortly after urine and blood sampling; the results were classified according to the International Society of Nephrology/Renal Pathology Society classification of LN by recording the activity score and chronicity score for each sample. Results There was a significant higher level of urinary IL-6 in the SLE patients with biopsy-proven LN than in those without LN and those of the control group. However, no significant difference was reported between the three groups as regards serum IL-6. A strong positive correlation was found between urinary IL-6 and renal disease activity based on the renal SLE disease activity index (SLEDAI) score with no significant correlation regarding the extra renal SLEDAI. Urinary IL-6 was positively correlated with renal biopsy results and with its activity scores but weakly correlated with the chronicity scores. Conclusion Urinary IL-6 may provide a simple noninvasive potential marker of disease activity of renal involvement in adult patients with SLE.https://doi.org/10.4137/CMAMD.S32269
collection DOAJ
language English
format Article
sources DOAJ
author Rawhya R. EL-Shereef
Ahmed Lotfi
Emad A. Abdel-Naeam
Heba Tawfik
spellingShingle Rawhya R. EL-Shereef
Ahmed Lotfi
Emad A. Abdel-Naeam
Heba Tawfik
Serum and Urinary Interleukin-6 in Assessment of Renal Activity in Egyptian Patients with Systemic Lupus Erythematosus
Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders
author_facet Rawhya R. EL-Shereef
Ahmed Lotfi
Emad A. Abdel-Naeam
Heba Tawfik
author_sort Rawhya R. EL-Shereef
title Serum and Urinary Interleukin-6 in Assessment of Renal Activity in Egyptian Patients with Systemic Lupus Erythematosus
title_short Serum and Urinary Interleukin-6 in Assessment of Renal Activity in Egyptian Patients with Systemic Lupus Erythematosus
title_full Serum and Urinary Interleukin-6 in Assessment of Renal Activity in Egyptian Patients with Systemic Lupus Erythematosus
title_fullStr Serum and Urinary Interleukin-6 in Assessment of Renal Activity in Egyptian Patients with Systemic Lupus Erythematosus
title_full_unstemmed Serum and Urinary Interleukin-6 in Assessment of Renal Activity in Egyptian Patients with Systemic Lupus Erythematosus
title_sort serum and urinary interleukin-6 in assessment of renal activity in egyptian patients with systemic lupus erythematosus
publisher SAGE Publishing
series Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders
issn 1179-5441
publishDate 2016-01-01
description Aim of the Work This study investigates whether serum and urinary interleukin-6 (IL-6) represent an early marker of kidney involvement and assesses the difference between them and renal biopsy in lupus nephritis (LN). Patients and Methods A total of 60 systemic lupus erythematosus (SLE) patients were compared to 20 healthy controls. Urinary and serum IL-6 were measured in both patients and controls. In addition, renal biopsy was done prior or shortly after urine and blood sampling; the results were classified according to the International Society of Nephrology/Renal Pathology Society classification of LN by recording the activity score and chronicity score for each sample. Results There was a significant higher level of urinary IL-6 in the SLE patients with biopsy-proven LN than in those without LN and those of the control group. However, no significant difference was reported between the three groups as regards serum IL-6. A strong positive correlation was found between urinary IL-6 and renal disease activity based on the renal SLE disease activity index (SLEDAI) score with no significant correlation regarding the extra renal SLEDAI. Urinary IL-6 was positively correlated with renal biopsy results and with its activity scores but weakly correlated with the chronicity scores. Conclusion Urinary IL-6 may provide a simple noninvasive potential marker of disease activity of renal involvement in adult patients with SLE.
url https://doi.org/10.4137/CMAMD.S32269
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