Assessment of blood gas analysis results and degree of infection in children with severe pneumonia and respiratory failure after NCPAP therapy

• Main Author: Yao Luo
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-09-01
• Series: Journal of Hainan Medical University
• Subjects: Severe pneumonia; Respiratory failure
• Online Access: http://www.hnykdxxb.com/PDF/201618/13.pdf

Objective: To analyze the blood gas analysis results and degree of infection in children with severe pneumonia and respiratory failure after NCPAP therapy. Methods: A total of 60 cases of children with severe pneumonia and respiratory failure who were treated in our hospital from August 2013 to August 2015 were included in the study and randomly divided into observation group and control group (n=30). Control group received routine anti-infection and oxygen inhalation by nasal tube, observation group received additional NCPAP therapy, and then differences in values of blood gas and oxygen metabolism indexes, resting pulmonary function, respiratory mechanics indexes and serum infection-related parameters were compared between two groups. Results: After observation group received NCPAP therapy, PaO2, PH, CaO2, DO2 and SaO2 values were higher than those of control group while PaCO2 and VO2 values were lower than those of control group; VC%, FVC%, FEV1%, PEF%, MMEF% and MVV% values were higher than those of control group; respiratory mechanics parameters PIP, PP, Pm, VE and R values were lower than those of control group; serum CHE and PA values were higher than those of control group while sTREM-1 and HMGB-1 values were lower than those of control group. Conclusion: NCPAP therapy can significantly optimize the respiratory function and promote the recovery from infection in children with severe pneumonia and respiratory failure, and it has positive clinical significance.