Oral CPSI-2364 Treatment Prevents Postoperative Ileus in Swine without Impairment of Anastomotic Healing

Oral CPSI-2364 Treatment Prevents Postoperative Ileus in Swine without Impairment of Anastomotic Healing

Background: Postoperative ileus (POI) is an iatrogenic complication of abdominal surgery, mediated by a severe inflammation of the muscularis externa (ME). We demonstrated that orally applicated CPSI-2364 prevents POI in rodents by blockade of p38 MAPK pathway and abrogation of NO production in macr...

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Bibliographic Details
Main Authors: Tim O. Vilz, Nils Sommer, Philip Kahl, Dimitrios Pantelis, Joerg C. Kalff, Sven Wehner
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Postoperative ileus
Muscularis externa
Intestinal inflammation
Anastomotic healing
Online Access:http://www.karger.com/Article/FullText/356575

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