Reactivity of Thiol-Rich Zn Sites in Diacylglycerol-Sensing PKC C1 Domain Probed by NMR Spectroscopy

Reactivity of Thiol-Rich Zn Sites in Diacylglycerol-Sensing PKC C1 Domain Probed by NMR Spectroscopy

Conserved homology 1 (C1) domains are peripheral zinc finger domains that are responsible for recruiting their host signaling proteins, including Protein Kinase C (PKC) isoenzymes, to diacylglycerol-containing lipid membranes. In this work, we investigated the reactivity of the C1 structural zinc si...

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Bibliographic Details
Main Authors: Taylor R. Cole, Tatyana I. Igumenova
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
protein kinase C
C1 domain
zinc finger
cadmium
thiol-rich sites
cysteine reactivity
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.728711/full

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