Enhanced in vitro dissolution of Iloperidone using Caesalpinia Pulcherrima mucoadhesive microspheres

• Main Authors: Pradum Pundlikrao Ige, Kapil Agrawal, Upesh Patil
• Format: Article
• Language: English
• Published: SpringerOpen 2015-03-01
• Series: Beni-Suef University Journal of Basic and Applied Sciences
• Subjects: Iloperidone; Caesalpinia pulcherrima mucilage; Spray drying; Mucoadhesive microspheres; Solubility enhancement
• Online Access: http://www.sciencedirect.com/science/article/pii/S2314853515000050

The aim of the present investigation was to improve the solubility and dissolution rate of Iloperidone. Microspheres containing Iloperidone were prepared by spray drying using mucilage extracted from seeds of Caesalpinia pulcherrima. The novelty of this work is that, the extraction of mucilage and its usage for preparation of drug loaded microspheres. The prepared microspheres were characterized by SEM, DSC, XRPD, FTIR, 1H-NMR, particle size, drug content, entrapment efficiency, in vitro dissolution and ex vivo mucoadhesion. Based on particle size, drug content, ex vivo mucoadhesive strength and in vitro drug release, the best formulation was optimized. Percent entrapment efficiency and mean particle size for optimized formulation was found to be 73.49 and 3.27 ± 1.23 μm, respectively. More precisely, mucilage of C. pulcherrima could be significant carrier of (drug and polymer ratio 1:5) microspheres for the development of oral drug delivery.