Clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivo
Abstract How information in the nervous system is encoded by patterns of action potentials (i.e. spikes) remains an open question. Multi-neuron patterns of single spikes are a prime candidate for spike time encoding but their temporal variability requires further characterisation. Here we show how k...
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2021-07-01
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doaj-2b78186dac124be09ddbe822363fcf9e2021-08-01T11:26:06ZengNature Publishing GroupScientific Reports2045-23222021-07-0111112010.1038/s41598-021-94002-0Clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivoJames B. Isbister0Vicente Reyes-Puerta1Jyh-Jang Sun2Illia Horenko3Heiko J. Luhmann4Oxford Centre for Theoretical Neuroscience and Artificial Intelligence, Department of Experimental Psychology, University of OxfordInstitute of Physiology, University Medical Center, Johannes Gutenberg UniversityInstitute of Physiology, University Medical Center, Johannes Gutenberg UniversityFaculty of Informatics, Universita della Svizzera ItalianaInstitute of Physiology, University Medical Center, Johannes Gutenberg UniversityAbstract How information in the nervous system is encoded by patterns of action potentials (i.e. spikes) remains an open question. Multi-neuron patterns of single spikes are a prime candidate for spike time encoding but their temporal variability requires further characterisation. Here we show how known sources of spike count variability affect stimulus-evoked spike time patterns between neurons separated over multiple layers and columns of adult rat somatosensory cortex in vivo. On subsets of trials (clusters) and after controlling for stimulus-response adaptation, spike time differences between pairs of neurons are “time-warped” (compressed/stretched) by trial-to-trial changes in shared excitability, explaining why fixed spike time patterns and noise correlations are seldom reported. We show that predicted cortical state is correlated between groups of 4 neurons, introducing the possibility of spike time pattern modulation by population-wide trial-to-trial changes in excitability (i.e. cortical state). Under the assumption of state-dependent coding, we propose an improved potential encoding capacity.https://doi.org/10.1038/s41598-021-94002-0 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
James B. Isbister Vicente Reyes-Puerta Jyh-Jang Sun Illia Horenko Heiko J. Luhmann |
spellingShingle |
James B. Isbister Vicente Reyes-Puerta Jyh-Jang Sun Illia Horenko Heiko J. Luhmann Clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivo Scientific Reports |
author_facet |
James B. Isbister Vicente Reyes-Puerta Jyh-Jang Sun Illia Horenko Heiko J. Luhmann |
author_sort |
James B. Isbister |
title |
Clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivo |
title_short |
Clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivo |
title_full |
Clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivo |
title_fullStr |
Clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivo |
title_full_unstemmed |
Clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivo |
title_sort |
clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivo |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-07-01 |
description |
Abstract How information in the nervous system is encoded by patterns of action potentials (i.e. spikes) remains an open question. Multi-neuron patterns of single spikes are a prime candidate for spike time encoding but their temporal variability requires further characterisation. Here we show how known sources of spike count variability affect stimulus-evoked spike time patterns between neurons separated over multiple layers and columns of adult rat somatosensory cortex in vivo. On subsets of trials (clusters) and after controlling for stimulus-response adaptation, spike time differences between pairs of neurons are “time-warped” (compressed/stretched) by trial-to-trial changes in shared excitability, explaining why fixed spike time patterns and noise correlations are seldom reported. We show that predicted cortical state is correlated between groups of 4 neurons, introducing the possibility of spike time pattern modulation by population-wide trial-to-trial changes in excitability (i.e. cortical state). Under the assumption of state-dependent coding, we propose an improved potential encoding capacity. |
url |
https://doi.org/10.1038/s41598-021-94002-0 |
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