Clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivo

Abstract How information in the nervous system is encoded by patterns of action potentials (i.e. spikes) remains an open question. Multi-neuron patterns of single spikes are a prime candidate for spike time encoding but their temporal variability requires further characterisation. Here we show how k...

Full description

Bibliographic Details
Main Authors: James B. Isbister, Vicente Reyes-Puerta, Jyh-Jang Sun, Illia Horenko, Heiko J. Luhmann
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-94002-0
id doaj-2b78186dac124be09ddbe822363fcf9e
record_format Article
spelling doaj-2b78186dac124be09ddbe822363fcf9e2021-08-01T11:26:06ZengNature Publishing GroupScientific Reports2045-23222021-07-0111112010.1038/s41598-021-94002-0Clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivoJames B. Isbister0Vicente Reyes-Puerta1Jyh-Jang Sun2Illia Horenko3Heiko J. Luhmann4Oxford Centre for Theoretical Neuroscience and Artificial Intelligence, Department of Experimental Psychology, University of OxfordInstitute of Physiology, University Medical Center, Johannes Gutenberg UniversityInstitute of Physiology, University Medical Center, Johannes Gutenberg UniversityFaculty of Informatics, Universita della Svizzera ItalianaInstitute of Physiology, University Medical Center, Johannes Gutenberg UniversityAbstract How information in the nervous system is encoded by patterns of action potentials (i.e. spikes) remains an open question. Multi-neuron patterns of single spikes are a prime candidate for spike time encoding but their temporal variability requires further characterisation. Here we show how known sources of spike count variability affect stimulus-evoked spike time patterns between neurons separated over multiple layers and columns of adult rat somatosensory cortex in vivo. On subsets of trials (clusters) and after controlling for stimulus-response adaptation, spike time differences between pairs of neurons are “time-warped” (compressed/stretched) by trial-to-trial changes in shared excitability, explaining why fixed spike time patterns and noise correlations are seldom reported. We show that predicted cortical state is correlated between groups of 4 neurons, introducing the possibility of spike time pattern modulation by population-wide trial-to-trial changes in excitability (i.e. cortical state). Under the assumption of state-dependent coding, we propose an improved potential encoding capacity.https://doi.org/10.1038/s41598-021-94002-0
collection DOAJ
language English
format Article
sources DOAJ
author James B. Isbister
Vicente Reyes-Puerta
Jyh-Jang Sun
Illia Horenko
Heiko J. Luhmann
spellingShingle James B. Isbister
Vicente Reyes-Puerta
Jyh-Jang Sun
Illia Horenko
Heiko J. Luhmann
Clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivo
Scientific Reports
author_facet James B. Isbister
Vicente Reyes-Puerta
Jyh-Jang Sun
Illia Horenko
Heiko J. Luhmann
author_sort James B. Isbister
title Clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivo
title_short Clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivo
title_full Clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivo
title_fullStr Clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivo
title_full_unstemmed Clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivo
title_sort clustering and control for adaptation uncovers time-warped spike time patterns in cortical networks in vivo
publisher Nature Publishing Group
series Scientific Reports
issn 2045-2322
publishDate 2021-07-01
description Abstract How information in the nervous system is encoded by patterns of action potentials (i.e. spikes) remains an open question. Multi-neuron patterns of single spikes are a prime candidate for spike time encoding but their temporal variability requires further characterisation. Here we show how known sources of spike count variability affect stimulus-evoked spike time patterns between neurons separated over multiple layers and columns of adult rat somatosensory cortex in vivo. On subsets of trials (clusters) and after controlling for stimulus-response adaptation, spike time differences between pairs of neurons are “time-warped” (compressed/stretched) by trial-to-trial changes in shared excitability, explaining why fixed spike time patterns and noise correlations are seldom reported. We show that predicted cortical state is correlated between groups of 4 neurons, introducing the possibility of spike time pattern modulation by population-wide trial-to-trial changes in excitability (i.e. cortical state). Under the assumption of state-dependent coding, we propose an improved potential encoding capacity.
url https://doi.org/10.1038/s41598-021-94002-0
work_keys_str_mv AT jamesbisbister clusteringandcontrolforadaptationuncoverstimewarpedspiketimepatternsincorticalnetworksinvivo
AT vicentereyespuerta clusteringandcontrolforadaptationuncoverstimewarpedspiketimepatternsincorticalnetworksinvivo
AT jyhjangsun clusteringandcontrolforadaptationuncoverstimewarpedspiketimepatternsincorticalnetworksinvivo
AT illiahorenko clusteringandcontrolforadaptationuncoverstimewarpedspiketimepatternsincorticalnetworksinvivo
AT heikojluhmann clusteringandcontrolforadaptationuncoverstimewarpedspiketimepatternsincorticalnetworksinvivo
_version_ 1721245972012466176