The Full Region of N-Terminal in Polymerase of IBDV Plays an Important Role in Viral Replication and Pathogenicity: Either Partial Region or Single Amino Acid V4I Substitution Does Not Completely Lead to the Virus Attenuation to Three-Yellow Chickens

The Full Region of N-Terminal in Polymerase of IBDV Plays an Important Role in Viral Replication and Pathogenicity: Either Partial Region or Single Amino Acid V4I Substitution Does Not Completely Lead to the Virus Attenuation to Three-Yellow Chickens

Infectious Bursal Disease Virus (IBDV) has haunted the poultry industry with severe, prolonged immunosuppression of chickens when infected at an early age and can easily lead to other secondary infections. Understanding the pathogenic mechanisms could lead to effective prevention and control of Infe...

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Bibliographic Details
Main Authors: Weiwei Wang, Yu Huang, Zhonghua Ji, Guo Chen, Yan Zhang, Yuanzheng Qiao, Mengya Shi, Min Li, Teng Huang, Tianchao Wei, Meilan Mo, Xiumiao He, Ping Wei
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Viruses
Subjects:
Infectious Bursal Disease Virus
N-terminal domain of VP1
reverse genetics technique
recombinant virus
viral replication and pathogenicity
Online Access:https://www.mdpi.com/1999-4915/13/1/107

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