Proteomics Analysis of Monocyte-Derived Hepatocyte-Like Cells Identifies Integrin Beta 3 as a Specific Biomarker for Drug-Induced Liver Injury by Diclofenac

Proteomics Analysis of Monocyte-Derived Hepatocyte-Like Cells Identifies Integrin Beta 3 as a Specific Biomarker for Drug-Induced Liver Injury by Diclofenac

Idiosyncratic drug-induced liver injury (iDILI) is a major cause of acute liver failure resulting in liver transplantation or death. Prediction and diagnosis of iDILI remain a great challenge, as current models provide unsatisfying results in terms of sensitivity, specificity, and prognostic value....

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Bibliographic Details
Main Authors: Diana Dragoi, Andreas Benesic, Garwin Pichler, Nils A. Kulak, Harald S. Bartsch, Alexander L. Gerbes
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
DILI
biomarker
proteomics
drug-development
monocyte-derived hepatocyte-like cells
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00699/full

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