Δ9-Tetrahydrocannabinol induces endocannabinoid accumulation in mouse hepatocytes: antagonism by Fabp1 gene ablation

Δ9-Tetrahydrocannabinol induces endocannabinoid accumulation in mouse hepatocytes: antagonism by Fabp1 gene ablation

Phytocannabinoids, such as Δ9-tetrahydrocannabinol (THC), bind and activate cannabinoid (CB) receptors, thereby “piggy-backing” on the same pathway's endogenous endocannabinoids (ECs). The recent discovery that liver fatty acid binding protein-1 (FABP1) is the major cytosolic “chaperone” protei...

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Bibliographic Details
Main Authors: Avery L. McIntosh, Gregory G. Martin, Huan Huang, Danilo Landrock, Ann B. Kier, Friedhelm Schroeder
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Journal of Lipid Research
Subjects:
fatty acid binding protein-1
binding
structure
metabolism
N-arachidonoylethanolamide
2-arachidonoylglycerol
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752033916X

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