Ivabradine Ameliorates Cardiac Diastolic Dysfunction in Diabetic Mice Independent of Heart Rate Reduction

Ivabradine Ameliorates Cardiac Diastolic Dysfunction in Diabetic Mice Independent of Heart Rate Reduction

Cardiac fibroblast (CF) proliferation and activation play important roles in cardiac fibrosis and diastolic dysfunction (DD), which are involved in fibrosis-associated cardiovascular diseases. A previous study showed that ivabradine, a specific heart rate (HR)-lowering agent, significantly ameliorat...

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Bibliographic Details
Main Authors:	Hao Xie, Xing-Yi Shen, Na Zhao, Peng Ye, Zhen Ge, Zuo-Ying Hu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-06-01
Series:	Frontiers in Pharmacology
Subjects:	ivabradine c-Jun N-terminal kinase p38 mitogen-activated protein kinase cardiac fibrosis cardiac diastolic dysfunction
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2021.696635/full

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