High Protein Diet and Phenylalanine Hydroxylase Activities in Rats
The effects of a diet of 85% casein on the activities of the phenylalanine hydroxylases of rat liver and kidney have been compared. Whereas only the tetrahydrobiopterin-dependent activity of rat hepatic phenylalanine hydroxylase is significantly stimulated, both the tetrahydrobiopterin-dependent and...
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| Format: | Article |
| Language: | English |
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De Gruyter
1989-11-01
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| Series: | Pteridines |
| Online Access: | https://doi.org/10.1515/pteridines.1989.1.4.235 |
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doaj-2b57223c804c407bb233be5897a368462021-09-05T13:59:58ZengDe GruyterPteridines0933-48072195-47201989-11-011423523810.1515/pteridines.1989.1.4.235High Protein Diet and Phenylalanine Hydroxylase Activities in RatsCarty Michael P.0Beirne Edel1Donlon John2Biochemistry Department, University College, Galway, IrelandBiochemistry Department, University College, Galway, IrelandBiochemistry Department, University College, Galway, IrelandThe effects of a diet of 85% casein on the activities of the phenylalanine hydroxylases of rat liver and kidney have been compared. Whereas only the tetrahydrobiopterin-dependent activity of rat hepatic phenylalanine hydroxylase is significantly stimulated, both the tetrahydrobiopterin-dependent and the dimethyltetrahydropterin- dependent activities of the renal enzyme are significantly decreased, after five days of feeding a casein diet. The animals fed a high protein diet for seven days have an increased rate of phenylalanine catabolism in vivo, which is also reflected in increased flux of label from phenylalanine into glucose. The regulation of phenylalanine metabolism, under these conditions, is discussed.https://doi.org/10.1515/pteridines.1989.1.4.235 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Carty Michael P. Beirne Edel Donlon John |
| spellingShingle |
Carty Michael P. Beirne Edel Donlon John High Protein Diet and Phenylalanine Hydroxylase Activities in Rats Pteridines |
| author_facet |
Carty Michael P. Beirne Edel Donlon John |
| author_sort |
Carty Michael P. |
| title |
High Protein Diet and Phenylalanine Hydroxylase Activities in Rats |
| title_short |
High Protein Diet and Phenylalanine Hydroxylase Activities in Rats |
| title_full |
High Protein Diet and Phenylalanine Hydroxylase Activities in Rats |
| title_fullStr |
High Protein Diet and Phenylalanine Hydroxylase Activities in Rats |
| title_full_unstemmed |
High Protein Diet and Phenylalanine Hydroxylase Activities in Rats |
| title_sort |
high protein diet and phenylalanine hydroxylase activities in rats |
| publisher |
De Gruyter |
| series |
Pteridines |
| issn |
0933-4807 2195-4720 |
| publishDate |
1989-11-01 |
| description |
The effects of a diet of 85% casein on the activities of the phenylalanine hydroxylases of rat liver and kidney have been compared. Whereas only the tetrahydrobiopterin-dependent activity of rat hepatic phenylalanine hydroxylase is significantly stimulated, both the tetrahydrobiopterin-dependent and the dimethyltetrahydropterin- dependent activities of the renal enzyme are significantly decreased, after five days of feeding a casein diet. The animals fed a high protein diet for seven days have an increased rate of phenylalanine catabolism in vivo, which is also reflected in increased flux of label from phenylalanine into glucose. The regulation of phenylalanine metabolism, under these conditions, is discussed. |
| url |
https://doi.org/10.1515/pteridines.1989.1.4.235 |
| work_keys_str_mv |
AT cartymichaelp highproteindietandphenylalaninehydroxylaseactivitiesinrats AT beirneedel highproteindietandphenylalaninehydroxylaseactivitiesinrats AT donlonjohn highproteindietandphenylalaninehydroxylaseactivitiesinrats |
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1717812645438947328 |