TRAIL Activates a Caspase 9/7-Dependent Pathway in Caspase 8/10-Defective SK-N-SH Neuroblastoma Cells with Two Functional End Points: Induction of Apoptosis and PGE2 Release

TRAIL Activates a Caspase 9/7-Dependent Pathway in Caspase 8/10-Defective SK-N-SH Neuroblastoma Cells with Two Functional End Points: Induction of Apoptosis and PGE2 Release

Most neuroblastoma cell lines do not express apical caspases 8 and 10, which play a key role in mediating tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) cytotoxicity in a variety of malignant cell types. In this study, we demonstrated that TRAIL induced a moderate but significant i...

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Bibliographic Details
Main Authors: Giorgio Zauli, Daniela Milani, Erika Rimondi, Giovanna Baldini, Vanessa Nicolin, Vittorio Grill, Paola Secchiero
Format: Article
Language:English
Published: Elsevier 2003-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
TRAIL
cell death
caspases
neuroblastoma
prostanoids
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558603800489

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