The archaeo-eukaryotic GINS proteins and the archaeal primase catalytic subunit PriS share a common domain
<p>Abstract</p> <p>Primase and GINS are essential factors for chromosomal DNA replication in eukaryotic and archaeal cells. Here we describe a previously undetected relationship between the C-terminal domain of the catalytic subunit (PriS) of archaeal primase and the B-domains of t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-04-01
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| Series: | Biology Direct |
| Online Access: | http://www.biology-direct.com/content/5/1/17 |
| Summary: | <p>Abstract</p> <p>Primase and GINS are essential factors for chromosomal DNA replication in eukaryotic and archaeal cells. Here we describe a previously undetected relationship between the C-terminal domain of the catalytic subunit (PriS) of archaeal primase and the B-domains of the archaeo-eukaryotic GINS proteins in the form of a conserved structural domain comprising a three-stranded antiparallel β-sheet adjacent to an α-helix and a two-stranded β-sheet or hairpin. The presence of a shared domain in archaeal PriS and GINS proteins, the genes for which are often found adjacent on the chromosome, suggests simple mechanisms for the evolution of these proteins.</p> <p>Reviewers</p> <p>This article was reviewed by Zvi Kelman (nominated by Michael Galperin) and Kira Makarova.</p> |
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| ISSN: | 1745-6150 |