Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association

Here, using high spatiotemporal resolution light-sheet and fluorescence microscopy, the authors investigate the role of cytoskeletal components on the intracellular transport of Rab11A and influenza virus (IAV) vRNP), and show a preference for Rab11A movement along microtubules that is not essential...

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Main Authors:	Amar R. Bhagwat, Valerie Le Sage, Eric Nturibi, Katarzyna Kulej, Jennifer Jones, Min Guo, Eui Tae Kim, Benjamin A. Garcia, Matthew D. Weitzman, Hari Shroff, Seema S. Lakdawala
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-13838-3

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spelling	doaj-2b51b06a55d942449a18150bc1abcd9c2021-05-11T09:08:39ZengNature Publishing GroupNature Communications2041-17232020-01-0111111410.1038/s41467-019-13838-3Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein associationAmar R. Bhagwat0Valerie Le Sage1Eric Nturibi2Katarzyna Kulej3Jennifer Jones4Min Guo5Eui Tae Kim6Benjamin A. Garcia7Matthew D. Weitzman8Hari Shroff9Seema S. Lakdawala10Department of Microbiology and Molecular Genetics, University of Pittsburgh School of MedicineDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of MedicineDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of MedicineThe Children’s Hospital of Philadelphia Research InstituteDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of MedicineSection on High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthThe Children’s Hospital of Philadelphia Research InstituteDepartment of Biochemistry and Biophysics, University of Pennsylvania Perelman School of MedicineThe Children’s Hospital of Philadelphia Research InstituteSection on High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of MedicineHere, using high spatiotemporal resolution light-sheet and fluorescence microscopy, the authors investigate the role of cytoskeletal components on the intracellular transport of Rab11A and influenza virus (IAV) vRNP), and show a preference for Rab11A movement along microtubules that is not essential for IAV vRNP transport.https://doi.org/10.1038/s41467-019-13838-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Amar R. Bhagwat Valerie Le Sage Eric Nturibi Katarzyna Kulej Jennifer Jones Min Guo Eui Tae Kim Benjamin A. Garcia Matthew D. Weitzman Hari Shroff Seema S. Lakdawala
spellingShingle	Amar R. Bhagwat Valerie Le Sage Eric Nturibi Katarzyna Kulej Jennifer Jones Min Guo Eui Tae Kim Benjamin A. Garcia Matthew D. Weitzman Hari Shroff Seema S. Lakdawala Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association Nature Communications
author_facet	Amar R. Bhagwat Valerie Le Sage Eric Nturibi Katarzyna Kulej Jennifer Jones Min Guo Eui Tae Kim Benjamin A. Garcia Matthew D. Weitzman Hari Shroff Seema S. Lakdawala
author_sort	Amar R. Bhagwat
title	Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association
title_short	Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association
title_full	Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association
title_fullStr	Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association
title_full_unstemmed	Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association
title_sort	quantitative live cell imaging reveals influenza virus manipulation of rab11a transport through reduced dynein association
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-01-01
description	Here, using high spatiotemporal resolution light-sheet and fluorescence microscopy, the authors investigate the role of cytoskeletal components on the intracellular transport of Rab11A and influenza virus (IAV) vRNP), and show a preference for Rab11A movement along microtubules that is not essential for IAV vRNP transport.
url	https://doi.org/10.1038/s41467-019-13838-3
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Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association

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