AMPA Receptor-mTOR Activation Is Required for the Antidepressant-like Effects of Sarcosine during the Forced Swim Test in rats: Insertion of AMPA Receptor may Play a Role

AMPA Receptor-mTOR Activation Is Required for the Antidepressant-like Effects of Sarcosine during the Forced Swim Test in rats: Insertion of AMPA Receptor may Play a Role

Sarcosine, an endogenous amino acid, is a competitive inhibitor of the type I glycine transporter and an N-methyl-D-aspartate receptor (NMDAR) coagonist. Recently, we found that sarcosine, an NMDAR enhancer, can improve depression-related behaviors in rodents and humans. This result differs from pre...

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Bibliographic Details
Main Authors: Kuang-Ti eChen, Mang-Hung eTsai, Ching-Hsiang eWu, Ming-Jia eJou, I-Hua eWei, Chih-Chia eHuang
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Depression
Sarcosine
NMDA
AMPA
mTOR
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2015.00162/full

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