| Summary: | Objective: The purpose of this study was to investigate the correlation between the FDG PET CT and histopathology in grading of gliomas.
Methods: 16 patients with clinically diagnosed glioma performed dual phase FDG PET CT of the brain for staging, and the staging was correlated to the histopathological classification in the surgical specimen.
Results: We found good correlation between the dual phase PET CT grading and the histopathological grading of gliomas, when a 23% increase was used as the cutoff for analysis of the difference in SUVmax of the lesion (L) versus normal gray matter (GM) over time, the sensitivity was 88.9%, the specificity was 85.7%, and the accuracy was 89.4% (P = 0.003; AUC = 0.94).
Conclusion: Dual phase FDG PET CT is a reliable predictor of proliferative activity of gliomas and could be used as a method of grading of the tumor.
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