Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment

Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment

Primary central nervous system lymphoma (PCNSL) is a group of extranodal non-Hodgkin lymphoma that exhibits specific biological characteristics and clinical behavior, with an aggressive disease course and unsatisfactory patient outcomes. It is of great importance to identify aberrant genetic loci an...

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Main Authors: Qingqing Cai, Yu Fang, Ken H. Young
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Translational Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523318305941
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spelling doaj-2b403b195daf4fbbbf22d5a3419963392020-11-25T00:30:37ZengElsevierTranslational Oncology1936-52332019-03-01123523538Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in TreatmentQingqing Cai0Yu Fang1Ken H. Young2Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P.R China; Address all correspondence to: Qingqing Cai, Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dong Feng Road East, Guangzhou 510060, P.R. China. or Ken H. Young, Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4009, USA.Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, P.R ChinaDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Address all correspondence to: Qingqing Cai, Department of Medical Oncology, Sun Yat-Sen University Cancer Center, 651 Dong Feng Road East, Guangzhou 510060, P.R. China. or Ken H. Young, Department of Hematopathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030-4009, USA.Primary central nervous system lymphoma (PCNSL) is a group of extranodal non-Hodgkin lymphoma that exhibits specific biological characteristics and clinical behavior, with an aggressive disease course and unsatisfactory patient outcomes. It is of great importance to identify aberrant genetic loci and important molecular pathways that might suggest potential targets for new therapeutics and provide prognostic information. In this review, we listed various genetic and epigenetic alterations that are involved in PCNSL pathogenesis. In the aspect of treatment, we summarized the related literatures and evaluated the efficacy of surgery, induction chemotherapy, radiotherapy, intrathecal chemotherapy, and autologous stem cell transplantation in PCNSL. We also proposed the possible new agents for recurrent and relapse PCNSL based on the result of recent clinical researches.http://www.sciencedirect.com/science/article/pii/S1936523318305941
collection DOAJ
language English
format Article
sources DOAJ
author Qingqing Cai
Yu Fang
Ken H. Young
spellingShingle Qingqing Cai
Yu Fang
Ken H. Young
Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment
Translational Oncology
author_facet Qingqing Cai
Yu Fang
Ken H. Young
author_sort Qingqing Cai
title Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment
title_short Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment
title_full Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment
title_fullStr Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment
title_full_unstemmed Primary Central Nervous System Lymphoma: Molecular Pathogenesis and Advances in Treatment
title_sort primary central nervous system lymphoma: molecular pathogenesis and advances in treatment
publisher Elsevier
series Translational Oncology
issn 1936-5233
publishDate 2019-03-01
description Primary central nervous system lymphoma (PCNSL) is a group of extranodal non-Hodgkin lymphoma that exhibits specific biological characteristics and clinical behavior, with an aggressive disease course and unsatisfactory patient outcomes. It is of great importance to identify aberrant genetic loci and important molecular pathways that might suggest potential targets for new therapeutics and provide prognostic information. In this review, we listed various genetic and epigenetic alterations that are involved in PCNSL pathogenesis. In the aspect of treatment, we summarized the related literatures and evaluated the efficacy of surgery, induction chemotherapy, radiotherapy, intrathecal chemotherapy, and autologous stem cell transplantation in PCNSL. We also proposed the possible new agents for recurrent and relapse PCNSL based on the result of recent clinical researches.
url http://www.sciencedirect.com/science/article/pii/S1936523318305941
work_keys_str_mv AT qingqingcai primarycentralnervoussystemlymphomamolecularpathogenesisandadvancesintreatment
AT yufang primarycentralnervoussystemlymphomamolecularpathogenesisandadvancesintreatment
AT kenhyoung primarycentralnervoussystemlymphomamolecularpathogenesisandadvancesintreatment
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