Scaffold-free 3D cell culture of primary skin fibroblasts induces profound changes of the matrisome

The human skin has a highly developed extracellular matrix (ECM) that is vital for proper skin functioning, its 3D architecture playing a pivotal role in support and guidance of resident and invading cells. To establish relevant in vitro models mimicking the complex design observed in vivo, scaffold...

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Bibliographic Details
Main Authors: Bich Vu, Glauco R. Souza, Jörn Dengjel
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Matrix Biology Plus
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2590028521000107