Differences between Mice and Humans in Regulation and the Molecular Network of Collagen, Type III, Alpha-1 at the Gene Expression Level: Obstacles that Translational Research Must Overcome

Differences between Mice and Humans in Regulation and the Molecular Network of Collagen, Type III, Alpha-1 at the Gene Expression Level: Obstacles that Translational Research Must Overcome

Collagen, type III, alpha-1 (COL3A1) is essential for normal collagen I fibrillogenesis in many organs. There are differences in phenotypes of mutations in the COL3A1 gene in humans and mutations in mice. In order to investigate whether the regulation and gene network of COL3A1 is the same in health...

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Bibliographic Details
Main Authors: Lishi Wang, Hongchao Liu, Yan Jiao, Erjian Wang, Stephen H. Clark, Arnold E. Postlethwaite, Weikuan Gu, Hong Chen
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:International Journal of Molecular Sciences
Subjects:
COL3A1
gene network
human
mouse
lung fibrosis
Online Access:http://www.mdpi.com/1422-0067/16/7/15031

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