H3K27me1 is essential for MMP-9-dependent H3N-terminal tail proteolysis during osteoclastogenesis

H3K27me1 is essential for MMP-9-dependent H3N-terminal tail proteolysis during osteoclastogenesis

Abstract Background MMP-9 plays a direct role in the activation of pro-osteoclastogenic genes by cleaving histone H3N-terminal tail (H3NT) and altering chromatin architecture. Although H3 acetylation at K18 has been shown to stimulate MMP-9 enzymatic activity toward H3NT, nothing is known about the...

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Bibliographic Details
Main Authors: Kyunghwan Kim, Yonghwan Shin, Jinman Kim, Tobias S. Ulmer, Woojin An
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Epigenetics & Chromatin
Subjects:
MMP-9
G9a
H3 proteolysis
H3K27me1
Osteoclast differentiation
Online Access:http://link.springer.com/article/10.1186/s13072-018-0193-1

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