Chronic lymphocytic leukaemia: contemporary conceptions of etiology, pathogenesis and peculiarities of clinical manifestations (review)

The research work presents an analysis of literature review and results of investigations on the problems of etiology, pathogenesis, classification and peculiarities of clinical manifestations of chronic lymphocytic leukaemia. Special attention is paid to both contemporary conceptions of carcinogene...

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Main Authors:	Chesnokova N.P., Shelekhova T.V., Zhevak T.N.
Format:	Article
Language:	Russian
Published:	Saratov State Medical University 2011-06-01
Series:	Саратовский научно-медицинский журнал
Subjects:	apoptosis C-reactive protein chronic lymphocytic leukaemia cytokines marker molecules proto-oncogenes
Online Access:	http://www.ssmj.ru/system/files/201102_376-385.pdf

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spelling	doaj-2b2374bb9c2a4229958cfd13e83dcf902021-07-02T01:01:46ZrusSaratov State Medical UniversityСаратовский научно-медицинский журнал1995-00392076-25182011-06-0172376385Chronic lymphocytic leukaemia: contemporary conceptions of etiology, pathogenesis and peculiarities of clinical manifestations (review) Chesnokova N.P.Shelekhova T.V.Zhevak T.N.The research work presents an analysis of literature review and results of investigations on the problems of etiology, pathogenesis, classification and peculiarities of clinical manifestations of chronic lymphocytic leukaemia. Special attention is paid to both contemporary conceptions of carcinogenesis, reflecting the role of proto-oncogenes activation, an-tioncogenes and apoptosis genes suppression in mechanisms of neoplasia development and «specific mechanisms» of oncogenic transformation induction of B-lymphocytes and the subsequent development of the stages of promotion, progression and marked clinical manifestations of formation. Possibility of further improvement of use of immune phe-notype character and oncomarkers in diagnostics of chronic lymphocytic leukaemia clinical variants and in evaluation of effectiveness of its therapy has been indicated in the articlehttp://www.ssmj.ru/system/files/201102_376-385.pdfapoptosisC-reactive proteinchronic lymphocytic leukaemiacytokinesmarker moleculesproto-oncogenes
collection	DOAJ
language	Russian
format	Article
sources	DOAJ
author	Chesnokova N.P. Shelekhova T.V. Zhevak T.N.
spellingShingle	Chesnokova N.P. Shelekhova T.V. Zhevak T.N. Chronic lymphocytic leukaemia: contemporary conceptions of etiology, pathogenesis and peculiarities of clinical manifestations (review) Саратовский научно-медицинский журнал apoptosis C-reactive protein chronic lymphocytic leukaemia cytokines marker molecules proto-oncogenes
author_facet	Chesnokova N.P. Shelekhova T.V. Zhevak T.N.
author_sort	Chesnokova N.P.
title	Chronic lymphocytic leukaemia: contemporary conceptions of etiology, pathogenesis and peculiarities of clinical manifestations (review)
title_short	Chronic lymphocytic leukaemia: contemporary conceptions of etiology, pathogenesis and peculiarities of clinical manifestations (review)
title_full	Chronic lymphocytic leukaemia: contemporary conceptions of etiology, pathogenesis and peculiarities of clinical manifestations (review)
title_fullStr	Chronic lymphocytic leukaemia: contemporary conceptions of etiology, pathogenesis and peculiarities of clinical manifestations (review)
title_full_unstemmed	Chronic lymphocytic leukaemia: contemporary conceptions of etiology, pathogenesis and peculiarities of clinical manifestations (review)
title_sort	chronic lymphocytic leukaemia: contemporary conceptions of etiology, pathogenesis and peculiarities of clinical manifestations (review)
publisher	Saratov State Medical University
series	Саратовский научно-медицинский журнал
issn	1995-0039 2076-2518
publishDate	2011-06-01
description	The research work presents an analysis of literature review and results of investigations on the problems of etiology, pathogenesis, classification and peculiarities of clinical manifestations of chronic lymphocytic leukaemia. Special attention is paid to both contemporary conceptions of carcinogenesis, reflecting the role of proto-oncogenes activation, an-tioncogenes and apoptosis genes suppression in mechanisms of neoplasia development and «specific mechanisms» of oncogenic transformation induction of B-lymphocytes and the subsequent development of the stages of promotion, progression and marked clinical manifestations of formation. Possibility of further improvement of use of immune phe-notype character and oncomarkers in diagnostics of chronic lymphocytic leukaemia clinical variants and in evaluation of effectiveness of its therapy has been indicated in the article
topic	apoptosis C-reactive protein chronic lymphocytic leukaemia cytokines marker molecules proto-oncogenes
url	http://www.ssmj.ru/system/files/201102_376-385.pdf
work_keys_str_mv	AT chesnokovanp chroniclymphocyticleukaemiacontemporaryconceptionsofetiologypathogenesisandpeculiaritiesofclinicalmanifestationsreview AT shelekhovatv chroniclymphocyticleukaemiacontemporaryconceptionsofetiologypathogenesisandpeculiaritiesofclinicalmanifestationsreview AT zhevaktn chroniclymphocyticleukaemiacontemporaryconceptionsofetiologypathogenesisandpeculiaritiesofclinicalmanifestationsreview
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Chronic lymphocytic leukaemia: contemporary conceptions of etiology, pathogenesis and peculiarities of clinical manifestations (review)

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