The non-homologous end-joining activity is required for Fanconi anemia fetal HSC maintenance

The non-homologous end-joining activity is required for Fanconi anemia fetal HSC maintenance

Abstract Background Recent studies have shown that deficiency in the Fanconi anemia (FA) DNA repair pathway enhances the error-prone non-homologous end-joining (NHEJ) repair, leading to increased genomic instability, and that genetic or pharmacological inhibition of the NHEJ pathway could rescue the...

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Bibliographic Details
Main Authors: Yan Nie, Yibo Li, Xiaoli Li, Andrew F. Wilson, Qishen Pang
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Stem Cell Research & Therapy
Subjects:
Fanconi anemia (FA)
Hematopoietic stem cells (HSCs)
Homologous recombination (HR)
Non-homologous end joining (NHEJ)
Online Access:http://link.springer.com/article/10.1186/s13287-019-1206-0

Internet

http://link.springer.com/article/10.1186/s13287-019-1206-0

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