Design, Synthesis, and Biological Evaluation of a Series of 5- and 7-Hydroxycoumarin Derivatives as 5-HT<sub>1A</sub> Serotonin Receptor Antagonists

Design, Synthesis, and Biological Evaluation of a Series of 5- and 7-Hydroxycoumarin Derivatives as 5-HT<sub>1A</sub> Serotonin Receptor Antagonists

We have designed and synthesized a series of 60 new 5- and 7-hydroxycoumarin derivatives bearing the piperazine moiety with the expected binding to 5-HT<sub>1A</sub> and 5-HT<sub>2A</sub> receptors. Molecular docking of all investigated compounds revealed subnanomolar estimat...

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Bibliographic Details
Main Authors: Kinga Ostrowska, Anna Leśniak, Zuzanna Czarnocka, Jagoda Chmiel, Magdalena Bujalska-Zadrożny, Bartosz Trzaskowski
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceuticals
Subjects:
molecular docking
microwave-assisted synthesis
hydroxycoumarin derivatives
5-HT<sub>1A</sub>
5-HT<sub>2A</sub>
receptors ligands
Online Access:https://www.mdpi.com/1424-8247/14/3/179

Internet

https://www.mdpi.com/1424-8247/14/3/179

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