Reliability of genomic variants across different next-generation sequencing platforms and bioinformatic processing pipelines

Reliability of genomic variants across different next-generation sequencing platforms and bioinformatic processing pipelines

Abstract Background Next Generation Sequencing (NGS) is the fundament of various studies, providing insights into questions from biology and medicine. Nevertheless, integrating data from different experimental backgrounds can introduce strong biases. In order to methodically investigate the magnitud...

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Bibliographic Details
Main Authors: Stephan Weißbach, Stanislav Sys, Charlotte Hewel, Hristo Todorov, Susann Schweiger, Jennifer Winter, Markus Pfenninger, Ali Torkamani, Doug Evans, Joachim Burger, Karin Everschor-Sitte, Helen Louise May-Simera, Susanne Gerber
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Genomics
Subjects:
Next-generation sequencing (NGS) technologies
Platform-biases
Healthy aging
Illumina
Wellderly
Longevity
Online Access:https://doi.org/10.1186/s12864-020-07362-8

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