Analgesia linked to Nav1.7 loss of function requires µ- and δ-opioid receptors [version 1; referees: 2 approved]

Analgesia linked to Nav1.7 loss of function requires µ- and δ-opioid receptors [version 1; referees: 2 approved]

Background: Functional deletion of the Scn9a (sodium voltage-gated channel alpha subunit 9) gene encoding sodium channel Nav1.7 makes humans and mice pain-free. Opioid signalling contributes to this analgesic state. We have used pharmacological and genetic approaches to identify the opioid receptors...

Full description

Bibliographic Details
Main Authors: Vanessa Pereira, Queensta Millet, Jose Aramburu, Cristina Lopez-Rodriguez, Claire Gaveriaux-Ruff, John N. Wood
Format: Article
Language:English
Published: Wellcome 2018-08-01
Series:Wellcome Open Research
Online Access:https://wellcomeopenresearch.org/articles/3-101/v1

Similar Items

Similar Items