Analgesia linked to Nav1.7 loss of function requires µ- and δ-opioid receptors [version 1; referees: 2 approved]
Background: Functional deletion of the Scn9a (sodium voltage-gated channel alpha subunit 9) gene encoding sodium channel Nav1.7 makes humans and mice pain-free. Opioid signalling contributes to this analgesic state. We have used pharmacological and genetic approaches to identify the opioid receptors...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wellcome
2018-08-01
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| Series: | Wellcome Open Research |
| Online Access: | https://wellcomeopenresearch.org/articles/3-101/v1 |