Single Dose of N-Acetylcysteine in Local Anesthesia Increases Expression of HIF1α, MAPK1, TGFβ1 and Growth Factors in Rat Wound Healing

Single Dose of N-Acetylcysteine in Local Anesthesia Increases Expression of HIF1α, MAPK1, TGFβ1 and Growth Factors in Rat Wound Healing

In this study, we aimed to investigate the influence of N-acetylcysteine (NAC) on the gene expression profile, neoangiogenesis, neutrophils and macrophages in a rat model of incisional wounds. Before creating wounds on the backs of 24 Sprague–Dawley rats, intradermal injections were made. Lidocaine–...

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Bibliographic Details
Main Authors: Wiktor Paskal, Michał Kopka, Albert Stachura, Adriana M. Paskal, Piotr Pietruski, Kacper Pełka, Alan E. Woessner, Kyle P. Quinn, Ryszard Galus, Jarosław Wejman, Paweł Włodarski
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
wound healing
skin
regeneration
N-Acetylcysteine
therapy
growth factor
Online Access:https://www.mdpi.com/1422-0067/22/16/8659

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