Arsenic and Mercury Containing Traditional Chinese Medicine (Realgar and Cinnabar) Strongly Inhibit Organic Anion Transporters, Oat1 and Oat3, In Vivo in Mice
Toxic heavy metals, including mercury (Hg) and arsenic (As), accumulate preferentially in kidneys and always cause acute renal failure. The aim of this study was to investigate whether these samples affect organic anion transporters, Oat1 and Oat3, in vivo in mice kidney. Mice (n=10) were orally tre...
Main Authors: | Wen-Hao Yu, Na Zhang, Jin-Feng Qi, Chen Sun, Yong-Hui Wang, Mei Lin |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2015-01-01
|
Series: | BioMed Research International |
Online Access: | http://dx.doi.org/10.1155/2015/863971 |
Similar Items
-
Advances in the safety evaluation of mineral medicines - Cinnabar and Realgar
by: Jing-Zhuo Tian, et al.
Published: (2019-01-01) -
The Herbal Constituents in An-Gong-Niu-Huang Wan (AGNH) Protect against Cinnabar- and Realgar-Induced Hepatorenal Toxicity and Accumulations of Mercury and Arsenic in Mice
by: Songsong Wang, et al.
Published: (2021-01-01) -
Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and Solutes
by: Wei Wu, et al.
Published: (2017-07-01) -
Arsenic sulfide, the main component of realgar, a traditional Chinese medicine, induces apoptosis of gastric cancer cells in vitro and in vivo
by: Zhang L, et al.
Published: (2014-12-01) -
Arsenic Bioaccessibility of Realgar Influenced by the Other Traditional Chinese Medicines in Niuhuang Jiedu Tablet and the Roles of Gut Microbiota
by: Wenfeng Xu, et al.
Published: (2019-01-01)