Superficial Vein Thrombosis as the Initial Manifestation of Protein S Deficiency in an Adolescent with Narcolepsy

Protein S (PS) deficiency and narcolepsy have a similar pathomechanism in view of autoimmunity, and they can develop following an infection. However, there is no previous report of a patient with narcolepsy associated with PS deficiency and the relationship between these two diseases has not yet bee...

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Bibliographic Details
Main Authors: Su-Hyun Han, Sang-Ahm Lee
Format: Article
Language:English
Published: Korean Society of Sleep Medicine 2016-06-01
Series:Sleep Medicine Research
Subjects:
Online Access:http://www.sleepmedres.org/upload/pdf/smr-7-1-39.pdf
Description
Summary:Protein S (PS) deficiency and narcolepsy have a similar pathomechanism in view of autoimmunity, and they can develop following an infection. However, there is no previous report of a patient with narcolepsy associated with PS deficiency and the relationship between these two diseases has not yet been investigated. PS deficiency may lead to coagulopathies, which can present as superficial or deep vein thrombosis and embolism. Therefore, here we describe a case of an 18-year-old man with narcolepsy who presented with superficial vein thrombosis associated with PS deficiency. Our case suggested that the development of PS deficiency and narcolepsy can be interrelated with each other.
ISSN:2093-9175
2233-8853