Frequency and distribution of the enteroendocrine cells in small and large intestine of one humped camel (Camelus dromedarius)

• Main Authors: Suha Rassol AL-Bdyry, Miran Abed Al-Ameer Alrammahi
• Format: Article
• Language: English
• Published: College of Veterinary Medicine 2016-06-01
• Series: Al-Qadisiyah Journal of Veterinary Medicine Sciences
• Online Access: http://www.qu.edu.iq/journalvm/index.php/vm_journal/article/view/383

Enteroendocrine cells in some portions of intestinal tract play as endocrine portion by secreting some hormones that play key roles in the regulation of certain important organs. The aim of this study is to examine in detail the relative frequency and regional distribution of enteroendocrine cells in some portions of the intestinal tract of the camels. The regional localization of the endocrine cells in some portion intestinal tract of the camels (Camelus dromedarius) are inspected using immunohistochemistry techniques. Specimens from eight Dromedarian camels (Camelus dromedarius) of both sexes with age ranging from 2 - 6 years are investigated. The immunohistochemistry was performed using chromogranin A (ChA) and four types of hormones. Immune detection findings demonstrated that in the camel small intestine, glucose-dependent insulinotropic peptide (GIP), glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2) and cholecystokinin (CCK) are expressed in a subset of epithelial cells along the crypt-villus axis. While, in the large intestine (colon) of camels, glucagon-like peptide-1(GLP-1) and glucagon-like peptide-2 (GLP-2) expressed in the colonic gland. The cells are contained gut hormones appeared to be either triangular or flask-like in shape as indicate that they are enteroendocrine cells. Immunohistochemistry of serial sections showed that (ChA), which is a specific marker for enteroendocrine cells, is indeed expressed with glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1(GLP-1), glucagon-like peptide-2(GLP-2) and cholecystokinin (CCK) confirms the site of expression to be in enteroendocrine cells. There is a caudal decrease in K-cells and I-cells along of the camel small intestine, while an increase in L-cells in the colon