The Effects of Early Life Stress, Postnatal Diet Modulation, and Long-Term Western-Style Diet on Later-Life Metabolic and Cognitive Outcomes

Early life stress (ES) increases the risk to develop metabolic and brain disorders in adulthood. Breastfeeding (exclusivity and duration) is associated with improved metabolic and neurocognitive health outcomes, and the physical properties of the dietary lipids may contribute to this. Here, we teste...

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Main Authors: Maralinde R. Abbink, Lidewij Schipper, Eva F.G. Naninck, Cato M.H. de Vos, Romy Meier, Eline M. van der Beek, Paul J. Lucassen, Aniko Korosi
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Nutrients
Subjects:
Online Access:https://www.mdpi.com/2072-6643/12/2/570
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spelling doaj-2aee54c27d5941ca99aa1c17c6c0472f2020-11-25T02:39:26ZengMDPI AGNutrients2072-66432020-02-0112257010.3390/nu12020570nu12020570The Effects of Early Life Stress, Postnatal Diet Modulation, and Long-Term Western-Style Diet on Later-Life Metabolic and Cognitive OutcomesMaralinde R. Abbink0Lidewij Schipper1Eva F.G. Naninck2Cato M.H. de Vos3Romy Meier4Eline M. van der Beek5Paul J. Lucassen6Aniko Korosi7Brain Plasticity Group, Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The NetherlandsDanone Nutricia Research, 3584 CT Utrecht, The NetherlandsBrain Plasticity Group, Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The NetherlandsBrain Plasticity Group, Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The NetherlandsBrain Plasticity Group, Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The NetherlandsDanone Nutricia Research, 3584 CT Utrecht, The NetherlandsBrain Plasticity Group, Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The NetherlandsBrain Plasticity Group, Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1098 XH Amsterdam, The NetherlandsEarly life stress (ES) increases the risk to develop metabolic and brain disorders in adulthood. Breastfeeding (exclusivity and duration) is associated with improved metabolic and neurocognitive health outcomes, and the physical properties of the dietary lipids may contribute to this. Here, we tested whether early life exposure to dietary lipids mimicking some physical characteristics of breastmilk (i.e., large, phospholipid-coated lipid droplets; Concept Nuturis® infant milk formula (N-IMF)), could protect against ES-induced metabolic and brain abnormalities under standard circumstances, and in response to prolonged Western-style diet (WSD) in adulthood. ES was induced by exposing mice to limited nesting material from postnatal day (P) 2 to P9. From P16 to P42, male offspring were fed a standard IMF (S-IMF) or N-IMF, followed by either standard rodent diet (SD) or WSD until P230. We then assessed body composition development, fat mass, metabolic hormones, hippocampus-dependent cognitive function, and neurogenesis (proliferation and survival). Prolonged WSD resulted in an obesogenic phenotype at P230, which was not modulated by previous ES or N-IMF exposure. Nevertheless, ES and N-IMF modulated the effect of WSD on neurogenesis at P230, without affecting cognitive function, highlighting programming effects of the early life environment on the hippocampal response to later life challenges at a structural level.https://www.mdpi.com/2072-6643/12/2/570early-stresspostnatal-dietary lipidscognitionneurogenesiswestern style dietmetabolism
collection DOAJ
language English
format Article
sources DOAJ
author Maralinde R. Abbink
Lidewij Schipper
Eva F.G. Naninck
Cato M.H. de Vos
Romy Meier
Eline M. van der Beek
Paul J. Lucassen
Aniko Korosi
spellingShingle Maralinde R. Abbink
Lidewij Schipper
Eva F.G. Naninck
Cato M.H. de Vos
Romy Meier
Eline M. van der Beek
Paul J. Lucassen
Aniko Korosi
The Effects of Early Life Stress, Postnatal Diet Modulation, and Long-Term Western-Style Diet on Later-Life Metabolic and Cognitive Outcomes
Nutrients
early-stress
postnatal-dietary lipids
cognition
neurogenesis
western style diet
metabolism
author_facet Maralinde R. Abbink
Lidewij Schipper
Eva F.G. Naninck
Cato M.H. de Vos
Romy Meier
Eline M. van der Beek
Paul J. Lucassen
Aniko Korosi
author_sort Maralinde R. Abbink
title The Effects of Early Life Stress, Postnatal Diet Modulation, and Long-Term Western-Style Diet on Later-Life Metabolic and Cognitive Outcomes
title_short The Effects of Early Life Stress, Postnatal Diet Modulation, and Long-Term Western-Style Diet on Later-Life Metabolic and Cognitive Outcomes
title_full The Effects of Early Life Stress, Postnatal Diet Modulation, and Long-Term Western-Style Diet on Later-Life Metabolic and Cognitive Outcomes
title_fullStr The Effects of Early Life Stress, Postnatal Diet Modulation, and Long-Term Western-Style Diet on Later-Life Metabolic and Cognitive Outcomes
title_full_unstemmed The Effects of Early Life Stress, Postnatal Diet Modulation, and Long-Term Western-Style Diet on Later-Life Metabolic and Cognitive Outcomes
title_sort effects of early life stress, postnatal diet modulation, and long-term western-style diet on later-life metabolic and cognitive outcomes
publisher MDPI AG
series Nutrients
issn 2072-6643
publishDate 2020-02-01
description Early life stress (ES) increases the risk to develop metabolic and brain disorders in adulthood. Breastfeeding (exclusivity and duration) is associated with improved metabolic and neurocognitive health outcomes, and the physical properties of the dietary lipids may contribute to this. Here, we tested whether early life exposure to dietary lipids mimicking some physical characteristics of breastmilk (i.e., large, phospholipid-coated lipid droplets; Concept Nuturis® infant milk formula (N-IMF)), could protect against ES-induced metabolic and brain abnormalities under standard circumstances, and in response to prolonged Western-style diet (WSD) in adulthood. ES was induced by exposing mice to limited nesting material from postnatal day (P) 2 to P9. From P16 to P42, male offspring were fed a standard IMF (S-IMF) or N-IMF, followed by either standard rodent diet (SD) or WSD until P230. We then assessed body composition development, fat mass, metabolic hormones, hippocampus-dependent cognitive function, and neurogenesis (proliferation and survival). Prolonged WSD resulted in an obesogenic phenotype at P230, which was not modulated by previous ES or N-IMF exposure. Nevertheless, ES and N-IMF modulated the effect of WSD on neurogenesis at P230, without affecting cognitive function, highlighting programming effects of the early life environment on the hippocampal response to later life challenges at a structural level.
topic early-stress
postnatal-dietary lipids
cognition
neurogenesis
western style diet
metabolism
url https://www.mdpi.com/2072-6643/12/2/570
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