Coxsackievirus cloverleaf RNA containing a 5' triphosphate triggers an antiviral response via RIG-I activation.

Coxsackievirus cloverleaf RNA containing a 5' triphosphate triggers an antiviral response via RIG-I activation.

Upon viral infections, pattern recognition receptors (PRRs) recognize pathogen-associated molecular patterns (PAMPs) and stimulate an antiviral state associated with the production of type I interferons (IFNs) and inflammatory markers. Type I IFNs play crucial roles in innate antiviral responses by...

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Bibliographic Details
Main Authors: Qian Feng, Martijn A Langereis, David Olagnier, Cindy Chiang, Roel van de Winkel, Peter van Essen, Jan Zoll, John Hiscott, Frank J M van Kuppeveld
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3997492?pdf=render

Internet

http://europepmc.org/articles/PMC3997492?pdf=render

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