Quantitative proteomic analysis of gene regulation by miR-34a and miR-34c.

microRNAs (miRNAs) repress target genes by destabilizing mRNAs and/or by inhibiting translation. The best known factor for target recognition is the so called seed--a short continuous region of Watson-Crick base pairing between nucleotides 2-7 of the miRNA and complementary sequences in 3' untr...

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Bibliographic Details
Main Authors: Olivia A Ebner, Matthias Selbach
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3956911?pdf=render